Linked Life Data

7506537

Source:http://linkedlifedata.com/resource/pubmed/id/7506537

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-2-10
pubmed:abstractText
The expression of nitric oxide synthase mRNA and the enzyme activity were studied in the hippocampus of rats treated with lithium chloride (LiCl; 12 mEqkg-1 i.p.) and tacrine (5 mgkg-1 i.p.). In comparison to vehicle treated animals, mRNA signal was augmented by 2-fold 24 h after administration of LiCl and by 4-fold 15 min after tacrine. In LiCl pretreated rats, tacrine yielded a 6-fold mRNA increase and this was prevented by corticosterone (35 mgkg-1, given i.p. 30 min before tacrine). Combined administration of LiCl and tacrine also produced an approx. 80% increase in Ca(2+)-calmodulin-dependent nitric oxide synthase activity. The present results represent the first demonstration that in the hippocampus mRNA expression of constitutive brain nitric oxide synthase can be augmented with consequent increase in nitric oxide synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
197
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1132-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Lithium and tacrine increase the expression of nitric oxide synthase mRNA in the hippocampus of rat.
pubmed:affiliation
Department of Experimental Medicine, University of Reggio, Calabria, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't