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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-12-28
|
| pubmed:abstractText |
Patients with uncomplicated hyperparasitemic falciparum malaria are usually given parenteral antimalarial treatment to prevent a progression to vital organ dysfunction and death. Since the oral artemisinin derivatives are more rapidly effective than other antimalarial drugs, we compared oral artesunate (4 mg/kg/day for three days with mefloquine 25 mg/kg on the second day) with an intravenous quinine loading dose (20 mg of salt/kg initially then 10 mg/kg every 8 hr, followed by mefloquine 25 mg/kg) in an open paired randomized trial in 60 patients with acute falciparum malaria and greater than 4% parasitemia, but no evidence of vital organ dysfunction. There were no deaths and none of the patients progressed to develop severe malaria. Oral artesunate treatment resulted in shorter median [range] times to fever clearance (19 hr [4-45] versus 47 hr [4-107]) (P < 0.0001), parasite clearance (36 hr [18-61] versus 82 hr [36-104]) (P < 0.0001), and discharge from the hospital (25 hr [12-44] versus 58 hr [24-115]) (P < 0.0001). There was no toxicity attributable to artesunate. The cure rates by day 28 were 70% (19 of 27) and 39% (11 of 27) in the artesunate and quinine groups, respectively (relative risk = 1.7; 95% confidence interval = 1.0-3.0). Oral artesunate was simpler, cheaper, safer, and more effective than intravenous quinine for the treatment of uncomplicated hyperparasitemia.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Artemisinins,
http://linkedlifedata.com/resource/pubmed/chemical/Mefloquine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinine,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/artesunate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-9637
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
522-5
|
| pubmed:dateRevised |
2010-8-25
|
| pubmed:meshHeading |
pubmed-meshheading:7485711-Administration, Oral,
pubmed-meshheading:7485711-Adolescent,
pubmed-meshheading:7485711-Adult,
pubmed-meshheading:7485711-Antimalarials,
pubmed-meshheading:7485711-Artemisinins,
pubmed-meshheading:7485711-Child,
pubmed-meshheading:7485711-Child, Preschool,
pubmed-meshheading:7485711-Drug Therapy, Combination,
pubmed-meshheading:7485711-Female,
pubmed-meshheading:7485711-Humans,
pubmed-meshheading:7485711-Infusions, Intravenous,
pubmed-meshheading:7485711-Malaria, Falciparum,
pubmed-meshheading:7485711-Male,
pubmed-meshheading:7485711-Mefloquine,
pubmed-meshheading:7485711-Parasitemia,
pubmed-meshheading:7485711-Quinine,
pubmed-meshheading:7485711-Sesquiterpenes,
pubmed-meshheading:7485711-Time Factors,
pubmed-meshheading:7485711-Treatment Outcome
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria.
|
| pubmed:affiliation |
Shoklo Malaria Research Unit, Mae Sod, Thailand.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|