|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007134,
umls-concept:C0017262,
umls-concept:C0035696,
umls-concept:C0036667,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0312418,
umls-concept:C0681842,
umls-concept:C1414406,
umls-concept:C1415900,
umls-concept:C1516084,
umls-concept:C2911684
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1995-12-1
|
|
pubmed:abstractText |
Alpha-interferon (IFN-alpha) has significant antitumor activity against advanced renal cell carcinoma (RC). Although numerous clinical trials reported major responses in approximately 15% of patients subjected to INF-alpha therapy, it has been impossible to predict which patients will respond to IFN-alpha. RC cell lines could be subdivided into those that are inhibited by IFN-alpha and those that are not. The expression of GP160 (Aminopeptidase a/kidney-associated differentiation antigens) correlated with resistance to IFN-alpha. In RC xenografts using a mouse model, though GP160(+) RC cell lines were resistant to IFN-alpha, GP160(-) RC cell lines were markedly sensitive to IFN-alpha.
|
|
pubmed:language |
jpn
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0021-5287
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
86
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1424-8
|
|
pubmed:dateRevised |
2011-7-28
|
|
pubmed:meshHeading |
pubmed-meshheading:7474630-Adult,
pubmed-meshheading:7474630-Aged,
pubmed-meshheading:7474630-Aged, 80 and over,
pubmed-meshheading:7474630-Aminopeptidases,
pubmed-meshheading:7474630-Animals,
pubmed-meshheading:7474630-Antineoplastic Agents,
pubmed-meshheading:7474630-Carcinoma, Renal Cell,
pubmed-meshheading:7474630-Female,
pubmed-meshheading:7474630-Glutamyl Aminopeptidase,
pubmed-meshheading:7474630-Humans,
pubmed-meshheading:7474630-Interferon-alpha,
pubmed-meshheading:7474630-Kidney Neoplasms,
pubmed-meshheading:7474630-Male,
pubmed-meshheading:7474630-Mice,
pubmed-meshheading:7474630-Middle Aged,
pubmed-meshheading:7474630-Polymerase Chain Reaction,
pubmed-meshheading:7474630-Predictive Value of Tests,
pubmed-meshheading:7474630-RNA, Messenger,
pubmed-meshheading:7474630-Remission Induction
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
[Expression of GP160 mRNA in renal cell carcinoma: an attempt to predict the sensitivity of IFN-alpha therapy].
|
|
pubmed:publicationType |
Journal Article,
English Abstract
|
