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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1981-3-17
|
| pubmed:abstractText |
A group of 1-thio-beta-L-fucopyranosides containing hexadecane, 9-octadecene, adamantane, 1,2-diphenyltetrafluoroethane, and 3-hexynyl- and 3,6-dioxaoctylcholesterols were synthesized as potential immunologic adjuvants. Many of these fucosyl lipids and 6-(5-cholesten-3 beta-yloxy)hexyl 1 thioglycosides were found to give good response to subunit A/Victoria influenza virus. Carbohydrates with L-fucose and D-galactose backbones appeared essential for adjuvant activity. Lactose which has a terminal D-galactose moiety was found to be active, whereas L-arabinose which lacks a 5-(hydroxymethyl) group was inactive.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1184-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7452668-Adjuvants, Immunologic,
pubmed-meshheading:7452668-Animals,
pubmed-meshheading:7452668-Antigens, Viral,
pubmed-meshheading:7452668-Chemical Phenomena,
pubmed-meshheading:7452668-Chemistry,
pubmed-meshheading:7452668-Female,
pubmed-meshheading:7452668-Glycolipids,
pubmed-meshheading:7452668-Influenza A virus,
pubmed-meshheading:7452668-Mice,
pubmed-meshheading:7452668-Mitogens,
pubmed-meshheading:7452668-Time Factors
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Glycolipids as potential immunologic adjuvants.
|
| pubmed:publicationType |
Journal Article
|