Linked Life Data

7452318

Source:http://linkedlifedata.com/resource/pubmed/id/7452318

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-3-24
pubmed:abstractText
Examination of brain biopsies from Alzheimer's patients by electron microscopy revealed two types of filaments in and around the argyrophile plaques. The first neurofibrillary tangles were in degenerating neuronal processes, and each twisted tubule was made up of paired helical filaments. The second type stained for amyloid and had the ultrastructural appearance of amyloid. Amyloid fibril material found in these plaques was studied by means of tilt-stage electron microscopy and compared with X-ray images of scale models of bifilar helix. The model fulfilled the structural criteria established by electron microscopy. These observations confirmed that each amyloid profile was composed of a pair of twisted tubules, each of which measured about 60 A in diameter.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
621-31
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
High-resolution electron microscopic analysis of the amyloid fibril in Alzheimer's disease.
pubmed:publicationType
Journal Article