Linked Life Data

7428684

Source:http://linkedlifedata.com/resource/pubmed/id/7428684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-1-29
pubmed:abstractText
Atrophy of muscles due to disuse is similar in form to glucocorticoid atrophy of the general body musculature. Because of this similarity, a hypothesis was formed which attributed the selective muscle atrophy resulting from immobilization to an increase in glucocorticoid sensitivity. As an initial test of this hypothesis, the thermodynamic characteristics of 3H-dexamethasone binding were examined in cytosol prepared from immobilized and contralateral control gastrocnemius muscles. We report here an increase in numbers of glucocorticoid receptors in immobilized muscles relative to contralateral controls, with no change in binding affinity. These findings support the hypothesis that selective muscle atrophy is a result of changes in glucocorticoid sensitivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1649-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Disuse atrophy of skeletal muscle is associated with an increase in number of glucocorticoid receptors.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't