Linked Life Data

7418544

Source:http://linkedlifedata.com/resource/pubmed/id/7418544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-12-18
pubmed:abstractText
Urinary catecholamines (Norepinephrine : NE, Epinephrine : E) methoxylated amines (Metanephrine : MN, Normetanephrine : NMN) and 3-methoxy-4-hydroxyphenylglycol (MHPG) have been studied in the Lyon hypertensive strain of rats (LHS) and their normotensive controls (LNS) at three ages (5, 9 and 21 weeks) characteristic of the development of hypertension. In 5-week-old rats, increased excretion of E, MN, NMN and early elevation of the ratio E/E+NE were observed, thus suggesting a sympatho-adrenal hyperactivity, with accelerated maturation of E secretion. At adult age, the excretion of most adrenergic metabolites was similar in the two strains of rats. However, the data from adult LHS are difficult to interpret because of a potential renal impairment at this age. Furthermore, there was a positive correlation between systolic blood pressure and urinary catecholamines at 5 weeks and 9 weeks of age but not at 21 weeks. It is suggested that the early sympathoadrenal hyperactivity, which disappears with age, may be related to the onset of hypertension in the Lyon strain of hypertensive rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0148-3927
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-307
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Urinary excretion of catecholamines and metabolites in the Lyon strain of genetic hypertensive rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't