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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1980-11-25
|
| pubmed:abstractText |
We have regularly observed alterations in the three-layered arrangement of cerebellar cortex surrounding fissura prima in normal adult and neonatal rats. In 90 of 110 rat brains analyzed, the cortical layers surrounding fissura prima were found to be altered from the four-layered (neonatal) or three-layered (adult) arrangement found in the majority of the remainder of cerebellar cortex. This common alteration extended long distances (as much as 320 microns) on either side of the midline, causing fissura prima to become more and more shallow from its lateral to medial extent. In sagittal sections at the lateral edge of the alteration in neonatal cerebellum, the external granular layer and pial cells disappeared, leaving an expanse of molecular layer lying between internal granular layer cells of lobules V and VI. Proceeding medially toward the midsagittal region, the cells of the internal granular layer of lobules V and VI were situated closer together and often merged. In such sections Purkinje cells did not usually remain in a monolayer, but were displaced, and clusters of these cells were sometimes found within the white matter. Various complex configurations of internal granular layer, molecular layer, and Purkinje cell groups surrounding fissura prima were commonplace in regions of cerebellum as far lateral as 320 microns on either side of the midsagittal plane. The greatest dorsoventral extent of such alterations measured was 400 microns. The presence of these previously unreported deviations is unrelated to experimental stress, as they occur spontaneously, possibly due to a vestigeal disorganization left in midline zones after early cell migration phases.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-9967
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
192
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
109-18
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1980
|
| pubmed:articleTitle |
Naturally occurring alterations of cortical layers surrounding the fissura prima of rat cerebellum.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|