Linked Life Data

7403220

Source:http://linkedlifedata.com/resource/pubmed/id/7403220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-10-27
pubmed:abstractText
The relationship between voluntary movement initiation (VMI) and caudate nucleus dopamine receptor dynamics was analyzed in two rat strains. Charles River CD/F F-344 (CR-CD/F) and Zivic-Miller CD (ZM-CD) rats (male, 125-150 g) were trained to rapidly release and reset a response lever to avoid electric shock. Whereas 86% of all CR-CD/Fs completed training, only 43% of the ZM-CDs were able to do so. Of those rats completing training, the CR-CD/Fs showed marginally higher avoidance percentage and significantly faster VMI latencies. Physiologically, the more behaviorally-successful CR-CD/Fs showed significantly higher affinity for binding than the trained ZM-CDs and the large group of ZM-CDs which could not be successfully trained. In contrast, the trained ZM-CDs showed significantly higher density of dopamine receptors Bmax than the ZM-CDs which failed to train and the trained CR-CD/Fs. The behavior-physiology continuum is summarized as follows: CR-CD/F Rats = highest affinity and lowest Bmax--rapid, highest percentage avoidance; Trained ZM-CD Rats = lowest affinity and highest Bmax--slower, high percentage avoidance; ZM-CD rats that failed training = intermediate affinity and Bmax--avoidance failure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Strain differences in dopamine receptor function and the initiation of movement.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.