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pubmed:abstractText |
The pharmacokinetics of a single oral dose of clomipramine were examined in a group of depressed patients, 8 female and 2 male with a mean age of 51 years (range 21-78). Their mean clomipramine half-life was 36 hours and mean plasma clomipramine clearance 73 litres per hour, with a wide range in each case. These results differ from those previously reported in volunteer subjects, who had shorter clomipramine half-lives. Pharmacokinetic studies should therefore be performed in patients undergoing treatment, rather than healthy volunteers.
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