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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1980-8-15
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pubmed:abstractText |
Cardiac arrhythmias were produced in Sprague-Dawley-derived rats by chloroform challenge. The incidence of cardiac arrhythmias so induced increased with age and as a function of dose after pretreatment with theophylline. The dose-response and time-action parameters of theophylline's predisposing action to chloroform-hypoxia-induced cardiac arrhythmias were determined. This information has been utilized to develop a cardiac antiarrhythmic screening test in unanesthetized rats which is presented in the following paper.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0301-4533
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
243
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-96
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7387263-Acetates,
pubmed-meshheading:7387263-Aminophylline,
pubmed-meshheading:7387263-Animals,
pubmed-meshheading:7387263-Anoxia,
pubmed-meshheading:7387263-Anti-Arrhythmia Agents,
pubmed-meshheading:7387263-Chloroform,
pubmed-meshheading:7387263-Drug Evaluation, Preclinical,
pubmed-meshheading:7387263-Electrocardiography,
pubmed-meshheading:7387263-Heart Rate,
pubmed-meshheading:7387263-Male,
pubmed-meshheading:7387263-Rats,
pubmed-meshheading:7387263-Theophylline,
pubmed-meshheading:7387263-Time Factors
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pubmed:year |
1980
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pubmed:articleTitle |
Development of a cardiac antiarrhythmic screening test utilizing theophylline in the rat.
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pubmed:publicationType |
Journal Article
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