Linked Life Data

7373039

Source:http://linkedlifedata.com/resource/pubmed/id/7373039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-7-22
pubmed:abstractText
The Farr assay and sucrose gradient ultracentrifugation were used to study the importance of kinetic factors on the size of antibody/DNA immune complexes prepared from SLE sera and dsDNA. We have found that significantly different numbers and sizes of antibody/DNA immune complexes can be formed by varying the time course of addition of a given amount of DNA to an SLE serum. For example, the introduction of additional DNA to a preincubated antibody-DNA system does not lead to reequilibration of that system with respect to the amount of DNA bound or the size of the complexes formed even after 1 hr at 37 degrees C. The potential implications of these observations with respect to the pathogenesis of SLE is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2571-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Stability of DNA/anti-DNA complexes. III. Kinetic control of immune complex size.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.