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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1979-4-26
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pubmed:abstractText |
A possible role of polynucleotide phosphorylase (PNPase) in the destruction of poly-A fragments located at the 3'-OH end of mRNA from rat liver polyribosomes was studied. Using hybridization of mRNP particles and mRNA with poly-U Sepharose 4B, it was found that polyribosomal PNPase in vitro destroys the poly-A sequences of approximately 25% of poly-A+ mRNA during the first minutes of incubation at a high rate. The destruction of the poly-A fragment of mRNA by PNPase is incomplete, since part of it is presumably protected by proteins firmly bound to the poly-A sequences of mRNA.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0320-9725
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1983-8
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:737213-Animals,
pubmed-meshheading:737213-Microsomes, Liver,
pubmed-meshheading:737213-Nucleic Acid Hybridization,
pubmed-meshheading:737213-Poly A,
pubmed-meshheading:737213-Polyribonucleotide Nucleotidyltransferase,
pubmed-meshheading:737213-RNA, Messenger,
pubmed-meshheading:737213-Rats,
pubmed-meshheading:737213-Ribonucleoproteins
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pubmed:year |
1978
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pubmed:articleTitle |
[Destruction of mRNA poly-A sequences by polynucleotide phosphorylase in rat liver microsomes].
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pubmed:publicationType |
Journal Article,
English Abstract
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