Linked Life Data

7357096

Source:http://linkedlifedata.com/resource/pubmed/id/7357096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-5-30
pubmed:abstractText
Use of the method of transmural nerve stimulation depends on the assumption that stimulation parameters can be chosen to selectively and maximally activate nerves without stimulating vascular smooth muscle directly. When commercial stimulators are used with low impedance electrodes, it may not be possible to validate this assumption, due to the limited current output in this situation. To circumvent this limitation a coupling device which provides a very low source impedance to the electrodes is described. Using this device in experiments on preparations of rabbit ear artery, we have demonstrated that it is possible to selectively activate nerves, without stimulating smooth muscle directly. Adrenergic nerve activation was blocked with guanethidine, phentolamine or tetrodotoxin, while responses to direct smooth muscle activation persist in the presence of these drugs. Appropriate parameters for supramaximal nerve stimulation vary with the type of preparation and electrode arrangement. The possibility of variation with tissue and species is also discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-6847
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Transmural nerve stimulation of blood vessels in vitro: a critical examination.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.