Linked Life Data

7352015

Source:http://linkedlifedata.com/resource/pubmed/id/7352015

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5745
pubmed:dateCreated
1980-3-24
pubmed:abstractText
The enteric nervous system (ENS) of the mammalian gut consists principally of two ganglionated plexuses, the myenteric and submucous, which are embedded in the gut wall. Little is known about the anatomical and functional connections between the two plexuses and further clarification of their relationship is of central importance for the understanding of the ENS. In the present study we have approached this problem in a new way, using methods we have previously developed for maintaining the myenteric and submucous plexuses separately in vitro for several weeks. In an immunohistochemical study of these preparations and also of sections from normal and extrinsically denervated gut wall, we have found evidence for reciprocal projections between the myenteric and submucous plexuses, by nerve fibres containing two putative neurotransmitters, vasoactive intestinal polypeptide (VIP) and substance P (ref. 5) (see Fig. 1). Our observations were supported by radioimmunoassay of tissue extracts. These results suggest that one of the roles of these peptides in the gut is to coordinate the function of the two enteric plexuses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
283
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-3
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Peptide-containing neurones connect the two ganglionated plexuses of the enteric nervous system.
pubmed:publicationType
Journal Article