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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1982-5-12
|
| pubmed:abstractText |
Normal and chronic granulomatous disease (CGD) neutrophils accumulated sulfamethoxazole (SMX) 3-fold and trimethoprim (TMP) 14-fold, possibly through a non-ionic diffusion and pH-partition mechanism. CGD neutrophils incubated with SMX/TMP after phagocytosis of S. aureus killed the bacteria. These findings explain the clinically observed beneficial effect of SMX/TMP in the treatment of infections in CGD and in other conditions characterized by impaired phagocyte microbicidal capacity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0018-022X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
579-88
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7333866-Drug Therapy, Combination,
pubmed-meshheading:7333866-Granulomatous Disease, Chronic,
pubmed-meshheading:7333866-Humans,
pubmed-meshheading:7333866-Neutrophils,
pubmed-meshheading:7333866-Phagocytosis,
pubmed-meshheading:7333866-Sulfamethoxazole,
pubmed-meshheading:7333866-Trimethoprim
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Chronic granulomatous disease: effect of sulfamethoxazole/trimethoprim on neutrophil microbicidal function.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|