Linked Life Data

7333794

Source:http://linkedlifedata.com/resource/pubmed/id/7333794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-5-21
pubmed:abstractText
Adult male guinea pigs were immunized with hepatitis B virus polypeptides prepared by Triton X-100 solubilization of purified 22-nm hepatitis B surface antigen (HBsAg) particles. A virus-specific subunit containing both the 28,000 molecular weight glycoprotein and the 23,000 molecular weight protein stimulated both cell-mediated and humoral immunity. A whole-blood-cell transformation assay additionally showed that the 64,000 molecular weight component of HBsAg, previously shown to contain host-specific antigens, also stimulated a cellular response to purified intact HBsAg particles, suggesting the additional presence of virus-specific material in this fraction. Immunization of animals with the 28,000--23,000 molecular weight polypeptides subsequently prepared in micelle form enhanced the demonstration of a cell-mediated reaction after only a single dose of immunogen. The results provide further evidence as to the suitability of HBsAg polypeptides prepared by Triton X-100 solubilization for hepatitis B prophylaxis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5526
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Induction of cell-mediated immunity to HBsAg polypeptides.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't