Linked Life Data

731729

Source:http://linkedlifedata.com/resource/pubmed/id/731729

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1979-3-13
pubmed:abstractText
[3 H] Cystine and 115mCd were incorporated into hepatic and renal Cd-thionein in response to sc administration of 4.4 mumol of Cd2+ containing 115mCd. Cd-thionein-bound 115mCd reached a plateau by 24 and 72 h after the Cd2+ injection in liver and kidney, respectively. The half-life (t1/2) of 3 H-labeled hepatic Cd-thionein was 3.5 d, whereas the average t1/2 of the soluble proteins was 3.7 d. The t1/2 of 3 H-labeled renal Cd-thionein was 3.7 d, whereas the average t1/2 of the soluble renal proteins was 3.8 d. In marked contrast, the 115mCd content of both hepatic and renal Cd-thionein was virtually unchanged, even 9 d after administration of this radionuclide. These data indicate that the protein moiety of metallothionein is degraded, although there appears to be a concomitant rebinding of Cd2+ to nascent thionein polypeptide chains. Thus the lack of metallothionein degradation per se does not account for the long-term retention of Cd2+ in liver and kidney during chronic exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-4108
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
805-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Degradation of cadmium-thionein in rat liver and kidney.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.