Linked Life Data

7316513

Source:http://linkedlifedata.com/resource/pubmed/id/7316513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-2-22
pubmed:abstractText
An outbreak of salivary syndrome in horses in North Carolina was investigated. Rhizoctonia leguminicola was the predominant fungus isolated from toxic red clover hay. The fungus was less prevalent in the hay after 10 months of storage, and the hay had also decreased in biological activity after 10 months. Toxic hay caused extreme salivation, piloerection, respiratory distress, and increased frequency of defecation when fed to guinea pigs, and purified extracts of toxic hay and pure slaframine elicited these same responses when injected intraperitoneally into guinea pigs. The freshly acquired hay, based on the biological (slobber-producing) activity in hay and in purified extracts, contained the equivalent to 50 to 100 ppm (50 to 100 microgram/g) of slaframine, but this level had decreased after 10 months by about 10-fold to about 7 ppm. Slaframine and seven synthetic derivates of slaframine were used in presumptive gas-liquid chromatographic identification of this mycotoxin. Slaframine (1-acetoxy-6-amino-octahydroindolizine) was identified in purified extracts of toxic hay by gas-liquid chromatography-mass spectrometry after preparative thin-layer chromatography. This was the first direct identification of slaframine in toxic red clove hay.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0099-2240
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1067-73
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Salivary syndrome in horses: identification of slaframine in red clover hay.
pubmed:publicationType
Journal Article