Linked Life Data

7310539

Source:http://linkedlifedata.com/resource/pubmed/id/7310539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1982-2-25
pubmed:abstractText
Recently cimetidine (Tagamet), a widely used drug for peptic ulcer disease, was found to decrease serum levels of calcium and immunoreactive parathyroid hormone in patients with hyperparathyroidism. Since parathyroid hormone action is closely related to calcium homeostasis, we studied the effect of cimetidine on intestinal calcium transport. An in vivo perfusion technique was used for the study of net transport and lumen to mucosa flux of 45calcium. Our results indicate a significant decrease in net calcium transport and lumen to mucosa flux of 45calcium in the rats injected with cimetidine, compared to control rats. Direct addition of cimetidine to the perfusion solution did not alter transport rates significantly. The mechanism by which cimetidine affects calcium transport may be secondary to its effect on the release of parathyroid hormone from the parathyroid gland or an effect on vitamin D metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2157-61
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Intestinal calcium transport: effect of cimetidine.
pubmed:publicationType
Journal Article