Linked Life Data

7306074

Source:http://linkedlifedata.com/resource/pubmed/id/7306074

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-1-20
pubmed:abstractText
The effect of chronic acid feeding and its subsequent withdrawal was determined on the amounts of the metabolic intermediates and enzymic activities of the purine nucleotide cycle. Sprague-Dawley rats were given 1.5% (w/v) NH4Cl in their drinking water for 5 days. The renal excretion of NH3 rose 70-fold and the rats developed acidosis. The amount of renal IMP rose from a control value of 4.5 +/- 2.2 to 20.4 +/- 3.7nmol/g of kidney after 48h of acid feeding (P less than 0.001) and fell to normal within 48h of the recovery. Adenylosuccinate concentrations fell from a control value of 4.5 +/- 0.9nmol/g of kidney to 1.2 +/- 0.3nmol/g (P less than 0.005) by day 5 of acidosis and continued to fall to undetectable values by 48h after recovery. The amount of AMP remained constant through the acid-feeding and the recovery periods. The activity of adenylosuccinate synthetase, the rate-limiting enzyme of the purine nucleotide cycle, paralleled the rise and fall in NH3 excretion. The activities of phosphate-dependent glutaminase and glutamate dehydrogenase were elevated during the acid-feeding and the recovery period. Thus changes in the purine nucleotide cycle correlate with changes in NH3 excretion to a more parallel degree than does the activity of glutaminase or glutamate dehydrogenase.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-1396, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-14861533, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-29492, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-35552, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-4260388, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-4632198, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-4671210, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-5435406, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-616359, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-681346, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-708390, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-7401451, http://linkedlifedata.com/resource/pubmed/commentcorrection/7306074-821968
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The purine nucleotide cycle in the regulation of ammoniagenesis during induction and cessation of chronic acidosis in the rat kidney.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.