Linked Life Data

7304760

Source:http://linkedlifedata.com/resource/pubmed/id/7304760

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-1-28
pubmed:abstractText
The fractional synthesis rate of collagen (the percent of total ventricular collagen synthesized in one day) was measured in the hearts of normal dogs and those with pulmonary artery stenosis using a continuous 6-h intravenous infusion of [14C]proline. The fractional synthesis rate in normal ventricles was slow, 0.56%/day, and it increased eightfold to 4.8%/day in the hypertrophying right ventricle after 5 days. After 12 and 28 days the synthesis rate was still significantly greater than in the control left ventricle, being 2.6 and 1.3%/day, respectively. However, the synthesis rate of noncollagen protein was significantly greater than normal at 5 days only. The collagen content (expressed as a mass fraction) of the right ventricle decreased over the first 12 days of hypertrophy but by 28 days was restored to the normal right ventricular value of 9.6 mg/g wet wt tissue. The total amount of collagen in the hypertrophied ventricle calculated from the synthesis rates was in accord with that measured chemically. In normal dogs the collage content of the right ventricle was greater than that of the left, and the epicardium contributed substantially to the total collagen in the ventricular walls.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
241
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H708-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Collagen synthesis and content in right ventricular hypertrophy in the dog.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't