Linked Life Data

7288624

Source:http://linkedlifedata.com/resource/pubmed/id/7288624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-12-21
pubmed:abstractText
Uricase from C. utilis and uricase to which polyethylene glycol had been attached were injected into leghorn cockerels in an attempt to lower plasma urate levels. Twenty units of either enzyme reduced urate levels to near zero for 24 hr on initial injection, whereas 10 U were effective for less than 6 hr. After injection with four-weekly doses of enzyme, unmodified uricase was ineffective in lowering plasma urate levels. Polyethylene glycol-uricase, however, was as effective as on the first injection. Both enzyme preparations appear in the lymph shortly after injection into the rat, although polyethylene glycol-uricase appears slightly sooner and maintains a more constant level than uricase.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
219
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
352-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Reduction of plasma urate levels in the cockerel with polyethylene glycol-uricase.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't