Linked Life Data

7284363

Source:http://linkedlifedata.com/resource/pubmed/id/7284363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-12-16
pubmed:abstractText
Papain treatment of renal brush border vesicles was carried out as a successful first step towards the purification of the membrane components involved in dipeptide transport. The treated vesicles exhibited increased specific transport activity of glycyl-L-proline. In contrast, the specific transport activity of L-alanine in the treated vesicles was less than that in the control vesicles. Papain treatment resulted in the solubilization of 38% of protein, 55% of alkaline phosphatase, 90% of gamma-glutamyltransferase and 95% of leucine aminopeptidase. There was no change in the intravesicular volume nor was there any increase in vesicular permeability. Glycyl-L-proline transport was Na+-independent in the control and papain-treated vesicles. Diamide reduced the Na+-dependent L-alanine transport while glycyl-L-proline transport remained unaffected in the presence of Na+. Many dipeptides inhibited glycyl-L-proline transport both in the presence and absence of Na+. The inhibition by dipeptides was greater than the inhibition by equivalent concentrations of free amino acids. These data demonstrate that renal brush border vesicles can efficiently handle dipeptides by a mechanism completely different from that of amino acid transport.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
642
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Evidence for a dipeptide transport system in renal brush border membranes from rabbit.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.