Linked Life Data

7282941

Source:http://linkedlifedata.com/resource/pubmed/id/7282941

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-11-18
pubmed:abstractText
There are conflicting reports on the effect of tris(hydroxymethyl)aminomethane (Tris) on smooth muscle contraction. Therefore, the effect of substitution of Tris for bicarbonate in physiological saline solution on smooth muscle contractility was investigated. Tris (25 mM) increased the amplitude without changing the frequency of spontaneous contractions in rat portal vein. Tris did not inhibit either norepinephrine-induced contractions in rat portal vein and aorta or histamine-induced contractions in taenia coli. When the pH of the Tris-buffered solution was lowered from the control value of 7.4 to 7.0, spontaneous contractions in portal vein as well as agonist-induced contractions in all of the above preparations were inhibited. Tris did not inhibit contractions induced by calcium in potassium-depolarized smooth muscle preparations if the Tris-buffered solution contained sufficient amounts of sodium ion (as did bicarbonate-buffered solution). These results suggest that Tris does not inhibit contractile responses of isolated vascular and intestinal smooth muscle preparations provided that the conditions other than the buffer system (especially pH of solution) are similar to those in bicarbonate-buffered solutions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
241
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H337-41
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Tris does not inhibit isolated vascular or intestinal smooth muscle contraction.
pubmed:publicationType
Journal Article