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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-10-25
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pubmed:abstractText |
The linear phenomenological equations of nonequilibrium thermodynamics are limited theoretically to near equilibrium although a number of biological systems have been shown to exhibit a "linear" relationship between steady-state flows and conjugate thermodynamic forces outside the range of equilibrium. We have found a multidimensional inflection point which can exist well outside the range of equilibrium around with enzyme-catalyzed reactions exhibit "linear" behavior between the logarithm of reactant concentrations and enzyme catalyzed flows. A set of sufficient conditions has been derived which can be applied to any enzyme mechanism to determine whether a multidimensional inflection point exists. The conditions do not appear overly restrictive and may be satisfied by a large variety of coupled enzyme reactions. It is thus possible that the linearity observed in some biological systems may be explained in terms of enzyme operating near this multidimensional point.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-11270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-13771349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-18906405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-19210996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-196630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-402477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-4213266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-4404469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-4576440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-4714445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-4884849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-5263005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-5713453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-5964690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-5964691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-743571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7260273-745431
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1980
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pubmed:articleTitle |
Nonequilibrium linear behavior of biological systems. Existence of enzyme-mediated multidimensional inflection points.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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