Linked Life Data

7242692

Source:http://linkedlifedata.com/resource/pubmed/id/7242692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-8-10
pubmed:abstractText
Alterations of cerebellar Purkinje cell responses to microiontophoretically applied noradrenaline (NA) were studied in rats after the destruction of NA-containing afferents and terminals by 6-hydroxydopamine (6-OHDA). An enhanced efficacy of NA action after 6-OHDA treatment was indicated by a significant reduction in the mean iontophoretic current required for a threshold depressant response to NA. A potentiation of gamma aminobutyric acid (GABA)-mediated inhibition by administration of NA, similar to that previously observed in control animals, was also reliably elicited in 6-OHDA pretreated rats. In addition, Purkinje cells appeared to demonstrate an increase in sensitivity to such facilitating actions of NA, defined here as "modulatory supersensitivity". In contrast to the prolonged synergistic interactions between NA and GABA observed in control animals, however, the enhancement of the amino acid response in 6-OHDA treated animals did not persist beyond the period of NA ejection and converted instead to a period of rebound insensitivity to GABA action. These results provide electrophysiological evidence for the emergence of supersensitivity to NA action in cerebellum after the loss of noradrenergic input from locus coeruleus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-1298
pubmed:author
pubmed:issnType
Print
pubmed:volume
315
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
GABA facilitation by noradrenaline shows supersensitivity in cerebellum after 6-hydroxydopamine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.