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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1981-8-20
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pubmed:abstractText |
Cytogenetic studies were performed on bone-marrow cells from 12 patients with urinary tract infections treated with trimethoprim-sulfamethoxazole (T + S). An increased number of micronuclei was presented in the patients compared with the control group, whereas structural chromosomal aberrations were not seen. The present study shows that T + S, like other folic acid antagonists, damage the human genetic material, and confirms that the micronucleus test is more sensitive than chromosome analysis in detecting a cytogenetic effect of chemical agents in man.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-5107
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
89
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
91-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7242550-Bone Marrow Cells,
pubmed-meshheading:7242550-Cell Nucleus,
pubmed-meshheading:7242550-Chromosome Aberrations,
pubmed-meshheading:7242550-Drug Combinations,
pubmed-meshheading:7242550-Female,
pubmed-meshheading:7242550-Humans,
pubmed-meshheading:7242550-Male,
pubmed-meshheading:7242550-Mutagenicity Tests,
pubmed-meshheading:7242550-Mutagens,
pubmed-meshheading:7242550-Sulfamethoxazole,
pubmed-meshheading:7242550-Trimethoprim
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pubmed:year |
1981
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pubmed:articleTitle |
Cytogenetic studies in patients treated with trimethoprim-sulfamethoxazole.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|