Linked Life Data

7240744

Source:http://linkedlifedata.com/resource/pubmed/id/7240744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-8-20
pubmed:abstractText
This study has demonstrated the presence of large granular lymphocytes (LGL) in the rat and implicated a central role for these cells in mediating natural killer (NK) cell activity in this species. The LGL frequency from various organs was shown to be: peripheral blood = lung greater than spleen greater than peritoneal exudate greater than lymph node. Little or no LGL were found in the thymus or bone marrow. This pattern was similar to the distribution of NK activity, except for the lungs, which had no detectable activity. These studies have also shown that discontinuous Percoll density gradients can be used to highly enrich or deplete LGL from both spleen and peripheral blood. Enriched LGL populations were shown to bind selectively to NK-susceptible target cells and to demonstrate very high NK cell cytolysis. Since human NK activity has also been found to be clearly associated with LGL, the present findings indicate that rats may provide a very useful animal model for detailed studies of the ontogeny, regulation, and in vivo relevance of NK cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
282-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.