Linked Life Data

7239129

Source:http://linkedlifedata.com/resource/pubmed/id/7239129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-8-27
pubmed:abstractText
Acute expansion of extracellular fluid volume during maximal water diuresis was induced in 8 chronic liver disease patients without clinical evidence of fluid retention, and in 8 controls. Fractional reabsorption of sodium was inferred in the proximal tubule, in the ascending limb of Henle's loop, and in the more distal site of the tubule. The results indicate that the significantly reduced increment of sodium excretion in cirrhotic patients was due to its augmented reabsorption in the proximal tubule. To establish whether there was a reduced activity of a natriuretic factor, a biologic assay was performed in 16 albino Wistar rats by using urine samples collected immediately after completion of a saline load and processed with gel filtration. The infusion of this fraction resulted in a significant lowering of the increment of urine output, and absolute and fractional sodium excretion only in the rats infused with urine extracts from cirrhotic patients. The results of this study raise the possibility that a reduced production of a natriuretic factor may play some role in the pathogenesis of sodium retention, which is observed in patients with cirrhosis of the liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-10
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Renal handling of sodium and water in early chronic liver disease. Evidence for a reduced natriuretic activity of the cirrhotic urinary extracts in rats.
pubmed:publicationType
Journal Article