pubmed:abstractText |
The effects of morphine administration on analgesia and running activity were studied in DBA/2 (DBA) and C57BL/6 (C57) mice respectively, injected with D-amino acids (D-AA) for 5 days. The results indicate a clear cross-tolerance between D-AA and morphine in DBA mice when analgesia is considered, while the stimulating effect of the opiate is not modified after D-AA pretreatment in the C57 strain.
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