Linked Life Data

7225069

Source:http://linkedlifedata.com/resource/pubmed/id/7225069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1981-6-13
pubmed:abstractText
To explain the teratogenic action of cyclophosphamide treatment during the preimplantation period (day 3; 60 mg/kg), the decidual reaction of the uterus was studied in the rat by light microscopy and autoradiography on day 4 (preimplantation period) and on days 5 and 6 (implantation period). On day 4, 24 h after cyclophosphamide treatment, the 3H-thymidine labelling index of the stroma cells beneath the uterine epithelium was significantly increased (33.7 +/- 5.2%) as compared to untreated control animals (6.5 +/- 0.4%). In addition, the surface of the uterine lumina appeared smoother in treated animals than in controls. On day 5 of gestation no difference could be detected autoradiographically between the uteri and treated and untreated animals. Histologically, however, the decidual reaction in treated animals occupied a larger area than in controls. On day 6 of pregnancy the 3H-labelling index of stroma cells surrounding the implantation site of treated animals was considerably reduced (10.7 vs. 32.8% in controls) and necrotic stroma cells were found in the area around the implantation site. Mechanisms inducing the decidual changes in cyclophosphamide-treated animals are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0067-7833
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-57
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Decidual changes in the rat following cyclophosphamide treatment before implantation.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't