Linked Life Data

7200569

Source:http://linkedlifedata.com/resource/pubmed/id/7200569

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-7-22
pubmed:abstractText
The induction of sister-chromatid exchanges (SCEs) and chromosomal aberrations in Chinese hamster ovary cells by doxorubicin (adriamycin), DHAQ and several related anthraquinone derivatives was investigated. Doxorubicin, DHAQ and some of its analogues exhibited genotoxic effects at 1 nM concentration. Among them, DHAQ possessed the strongest activity. The DNA-damaging action of these substituted anthraquinone compounds correlated well with their antiproliferative effect on cells, and this action was detectable at concentrations significantly below that which caused inhibition of cell proliferation. Our data suggest that the genotoxic effects of the compounds occur prior to manifestation of their antiproliferative activity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-86
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Sister-chromatid exchange and chromosomal aberrations by DHAQ and related anthraquinone derivatives in Chinese hamster ovary cells.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.