Linked Life Data

7199309

Source:http://linkedlifedata.com/resource/pubmed/id/7199309

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1982-4-12
pubmed:abstractText
Doxycycline levels in various organs of mice after i.v. and p.o. administration were measured by a high-performance liquid chromatography method. When given as a single dose (50 mg/kg) i.v. doxycycline accumulated in the lung. High concentrations were also measured in liver and kidneys. When 50 mg/kg doxycycline were administered by stomach tube to fed mice the antibiotic accumulated to a lesser degree in the lung. On the other hand, the antibiotic levels in the liver and the kidneys were higher as after i.v. injection. The absorption of doxycycline administered p.o. was about 92% and seemed not to be influenced by food in the stomach. The elimination half-life in mice was 170 min independent of the route of administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2116-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Comparison of distribution of doxycycline in mice after oral and intravenous application measured by a high-performance liquid chromatographic method.
pubmed:publicationType
Journal Article