Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-2-12
pubmed:abstractText
Groups of rats were subcutaneously implanted with ALZET 2001 type osmotic minipumps containing d-amphetamine. Three doses of amphetamine (calculated as 0.47, 0.94 and 1.41 mg/kg/hour; measured values were approximately 50% lower), continuously released for 7 days, initially produced locomotor stimulation and stereotyped behavior slightly increasing over the first few days. During the later days, however, locomotor stimulation and stereotyped behavior markedly declined indicating tolerance development. These results contrast the often reported development of sensitization to the behavioral effect of amphetamine observed with repeated injections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Rapid decline of stereotyped behavior in rats during constant one week administration of amphetamine via implanted ALZET osmotic minipumps.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't