Linked Life Data

7196756

Source:http://linkedlifedata.com/resource/pubmed/id/7196756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1981-10-25
pubmed:abstractText
The effects of carbocromen on myocardial substrate uptake, myocardial oxygen consumption (MVO2), and the mechanical activity of the heart was studied in eight intact, anaesthetized dogs. Carbocromen was given i.v. as an injection of 2 mg/kg body weight, and measurements performed in the basal condition and during isoprenaline infusion. Carbocromen increased myocardial blood flow and reduced coronary vascular resistance 15 and 30 min after administration, whereas these values returned to normal after 60 min. The myocardial performance, net myocardial uptake of free fatty acids (FFA), glucose and lactate and MVO2 were not changed by carbocromen. A second isoprenaline infusion 90 min following carbocromen administration induced changes in myocardial performance, net substrate uptake and oxygen consumption not significantly different from isoprenaline infusion prior to carbocromen administration. The antianginal effects by carbocromen observed in clinical studies are more likely to be mediated through its known coronary vasodilator effect than any influence on myocardial metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1088-91
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Acute effects of the coronary vasodilator carbocromen on myocardial oxygen consumption, substrate uptake and mechanical performance in intact dogs.
pubmed:publicationType
Journal Article