Linked Life Data

7191225

Source:http://linkedlifedata.com/resource/pubmed/id/7191225

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1980-11-25
pubmed:abstractText
The present investigation was designed to demonstrate whether depression of cell-mediated immunity in tumor-bearing hosts is potentiated by halothane anesthesia. Both the in vivo and in vitro effects of halothane anesthesia on splenic lymphocytes from normal and tumor-bearing C3Hf/He mice were examined by lymphocyte transformation. The stimulation index (SI) of lymphocytes from normal C3Hf/He mice exposed to 1.5% halothane/98.5% oxygen anesthesia was significantly less than that of lymphocytes from normal C23Hf/He mice exposed to oxygen (SI of 25.3 and 33.6, respectively) (p < 0.001). Lymphocytes from tumor-bearing C3Hf/He mice demonstrated the greatest degree of immunosuppression by halothane when compared to those of normal (non-tumor-bearing) mice. That the tumor was the principal immunosuppressive factor was demonstraed by the SI of 34.6 for the non-tumor-bearing mouse lymphocytes and 4.1 for those of the mice with fibrosarcomas (p < 0.001). Lymphocytes from tumor-bearing hosts exposed to 1.5% halothane anesthesia demonstrated diminished lymphocyte transformation compared with those from control (tumor-bearing) mice exposed to oxygen (SI of 1.7 and 4.4, respectively) (p < 0.001). In both tumor-bearing and normal mice, there was a significant suppression of the cell-mediated immune response when the animals were exposed to halothane compared to exposure to oxygen. Results of this investigation demonstrate that halothane anesthesia potentiates the suppression of cell-mediated immunity observed in tumor-bearing hosts.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
666-71
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Halothane-induced suppression of cell-mediated immunity in normal and tumor-bearing C3Hf/He mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.