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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
|
| pubmed:dateCreated |
1983-12-20
|
| pubmed:abstractText |
Kinetics of thermal decomposition of trihydrate of sodium salt of 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonic acid (MDS, vitamin K3 soluble form) in solid state by accelerated aging method at elevated temperature has been studied. It was found that the process occurs according to Prout-Tompkins model and its rate depends on temperature, humidity and particle size of the substance. Thermodynamic parameters of the reaction (Q10(0), EA, delta H not equal to, delta S not equal to, delta G) were determined and theoretically predicted stability of MDS at room temperature is given. The reaction mechanism assumes a preliminary dehydration occurring via the successive elimination of one and a half, two and a half and finally three molecules of water. The obtained anhydrous form decomposes thermally forming free radical intermediates and yielding finally 2-methyl-1,4-naphthoquinone (vitamin K3), SO2 and NaOH.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-0244
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
399-408
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading | |
| pubmed:articleTitle |
Kinetics of drug decomposition. Part 73. Kinetics and mechanism of vitamin K3 soluble form thermal decomposition in solid phase.
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| pubmed:publicationType |
Journal Article
|