Linked Life Data

7162341

Source:http://linkedlifedata.com/resource/pubmed/id/7162341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20-21
pubmed:dateCreated
1983-4-21
pubmed:abstractText
Bombesin (0.001-0.125 microgram) elicits dose-related excessive grooming when administered i.c.v. to rats. In contrast to the grooming produced by various other endogenous and exogenous agents, bombesin-induced grooming is not markedly affected by behaviorally non-depressant doses (determined by a novel method) of morphine (3 and 10 mg/kg, s.c.). The benzomorphan, ethylketocyclazocine (0.25-0.5 mg/kg, s.c.), does attenuate bombesin-induced grooming in a dose-related and stereospecific manner. In this study, we have classified 27 opioids on the basis of their ability to antagonize bombesin-induced grooming. The results of the classification indicate that a benzomorphan nucleus is required for activity in this test. Our test provides evidence that postulated benzomorphan binding sites are functionally active as pharmacologic receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2229-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Classification of opioids on the basis of their ability to antagonize bombesin-induced grooming in rats.
pubmed:publicationType
Journal Article, Comparative Study