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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-3-11
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pubmed:abstractText |
The potency of two beta-endorphin fragments, des-Tyr1-gamma-endorphin (DT gamma E, beta E-(2-17) and des-enkephalin-gamma-endorphin (DE gamma E-(6-17) was compared on extinction of pole-jumping avoidance behavior and on retention of a one-trial step-through passive avoidance procedure. Both peptides facilitated the extinction of pole-jumping avoidance behavior and attenuated passive avoidance behavior. The gamma-type endorphin exhibited an inverted U-shaped dose-response curve on passive avoidance behavior but not on extinction of pole-jumping avoidance behavior. DE gamma E appeared to be approximately three times more potent than DT gamma E on extinction of pole-jumping avoidance behavior but one hundred times more potent on passive avoidance behavior. It is suggested that DE gamma E rather than DT gamma E represents the endogenous neuroleptic-like neuropeptide derived from beta-endorphin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Endorphin,
http://linkedlifedata.com/resource/pubmed/chemical/des-enkephalin-gamma-endorphin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-endorphin, des-Tyr(1)-
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7151858-Animals,
pubmed-meshheading:7151858-Avoidance Learning,
pubmed-meshheading:7151858-Behavior, Animal,
pubmed-meshheading:7151858-Dose-Response Relationship, Drug,
pubmed-meshheading:7151858-Endorphins,
pubmed-meshheading:7151858-Male,
pubmed-meshheading:7151858-Peptide Fragments,
pubmed-meshheading:7151858-Rats,
pubmed-meshheading:7151858-Rats, Inbred Strains,
pubmed-meshheading:7151858-beta-Endorphin
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pubmed:year |
1982
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pubmed:articleTitle |
Effect of des-Tyr1-gamma-endorphin and des-enkephalin-gamma-endorphin on active and passive avoidance behavior of rats; a dose-response relationship study.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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