Linked Life Data

7151062

Source:http://linkedlifedata.com/resource/pubmed/id/7151062

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-3-24
pubmed:abstractText
The sialic acid content and the activities of the enzymes responsible for the activation, transfer, and hydrolysis of sialic acid were determined in the livers of male Sprague-Dawley rats maintained on diets containing the hepatocarcinogen 2-acetylaminofluorene (AAF). The incidence of hyperplastic lesions was modulated by dietary fat and by the presence of a synthetic antioxidant. The purified diets utilized differed in the amount and degree of unsaturation of the lipid component; they contained either 20% corn oil, 18% coconut oil + 2% linoleic acid, or only 2% linoleic acid, and each diet was prepared either with or without 0.3% butylated hydroxytoluene (BHT). The supplementation of diets with BHT greatly retarded the development of hyperplastic nodules compared to unsupplemented diets. The AAF-treated rats and age-matched controls fed AAF-free diets were killed after a 12 to 17-week period of dietary treatment, and the livers were removed for histological and biochemical studies. Significant increases in sialic acid content, and in the activities of CMP-sialic acid synthetase and neuraminidase were observed in the livers from AAF-treated rats. The BHT supplementation of the AAF-containing diets resulted in livers with lower levels of sialic acid and CMP-sialic acid synthetase activities. The chemical and enzymatic changes observed in AAF-treated rats are consistent with an increased turnover of sialoglycoconjugates during the carcinogenic process.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-090X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-300
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Sialic acid metabolism in rats undergoing chemically induced hepatocarcinogenesis in specific dietary states.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.