Linked Life Data

7150966

Source:http://linkedlifedata.com/resource/pubmed/id/7150966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1983-3-24
pubmed:abstractText
Binding of [3H]corticosterone was examined in the soluble fraction (100,000 g) from superior cervical ganglia dissected from adrenalectomized and perfused rats. A large binding capacity (2100 fmol/mg protein) was found. However, no binding for [3H]-dexamethasone and [3H]triamcinolone was detected. The binding protein present in the ganglion preparation was characterized by DEAE-cellulose and DNA-cellulose chromatography and by isoelectric focusing. The corticosterone binding protein from the ganglia was found to be different from the cytoplasmic glucocorticoid receptor, but similar to plasma transcortin. A large portion (approximately 75%) of the transcortin-like [3H]corticosterone binding protein was located in the interstitial space between the sheath and the ganglionic cells. However, 25% of the binding protein was retained in the desheathed ganglion even after extensive washing with saline. Our findings indicate that cytoplasmic glucocorticoid receptors are not present in the superior cervical ganglion. It is possible that the transcortin-like protein associated with the desheathed ganglion may be intracellular, as other investigators have suggested similar intracellular presence of a transcortin-like protein in the liver, uterus, and pituitary.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
253
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[3H] Corticosterone binding in rat superior cervical ganglion.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.