Linked Life Data

7147610

Source:http://linkedlifedata.com/resource/pubmed/id/7147610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-1-7
pubmed:abstractText
Twenty one- to two-month-old Holstein, Angus, or Holstein-Angus crossbred calves were given intravenous complete Freund's adjuvant and their lungs were examined at 24 hours to 30 days post-injection. Two calves given intravenous saline served as normal controls. The evolving pulmonary inflammatory response was characterized initially by multifocal vasculitis and acute multifocal exudative pneumonitis which progressed to a granulomatous interstitial pneumonitis by seven days post-injection. Discrete granulomas characterized the lesions in the lungs and lymph nodes at 30 days post-injection, and granulomas also were seen in liver, kidney, and spleen. Clinically, the calves were tachypneic and pyrexic during the first week post-injection. Four calves developed acute pulmonary edema and died during, or shortly after, administration of the adjuvant. This model of experimental pneumonia in calves is similar to complete Freund's adjuvant-induced experimental pneumonia in other species. It is reproducible and predictable in its course of development and resolution, and provides a useful model for studying basic mechanisms of pulmonary inflammatory injury and repair in the bovine lung.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0300-9858
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
506-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The bovine pulmonary inflammatory response: adjuvant pneumonitis in calves.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.