Linked Life Data

7131856

Source:http://linkedlifedata.com/resource/pubmed/id/7131856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-12-18
pubmed:abstractText
The lung recovery assay for schistosomula has been used as a rapid method for measuring acquired resistance to Schistosoma mansoni infection in challenged animals. This assay method was successfully utilized in the present study with S. japonicum in mice. Assay of resistance to reinfection with the lung recovery technique and with the conventional perfusion method demonstrated that a considerable level of resistance developed in mice which had received the primary infection of 30 S. japonicum cercariae 8 weeks prior challenge infection. In a histological study of this period, as early as 4 hours after challenge exposure there was already a dense accumulation of cells around a small proportion of schistosomula in the immune mouse skin. Light and electron microscopy revealed that the adherent cells were mainly neutrophils. There was a more increase in the cellular reaction around the schistosomula in the skin 24 hours after challenge and the cells of this reaction were still predominantly neutrophils with a few eosinophils. A small proportion of these entrapped schistosomula showed structural damage. In contrast, schistosomula in the lungs of immune mice were essentially without cellular association. It appears from our work that the adherence of neutrophils to schistosomula in immune mouse skin contributes to a reduction in the number of worms which subsequently develop.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-5031
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Resistance of mice to secondary infection with Schistosoma japonicum, with special reference to neutrophil enriched response to schistosomula in the skin of immune mice.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't