Linked Life Data

7127094

Source:http://linkedlifedata.com/resource/pubmed/id/7127094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-12-16
pubmed:abstractText
Intracellular recordings from mouse spinal neurons grown dissociated in tissue culture were used to study the effects of the water soluble benzodiazepine, flurazepam, upon neuronal excitability. Low concentrations of this drug (1 pM to 10 nM) depressed excitability in three distinctly different ways: (1) by directly increasing Cl- conductance, (2) by potentiating responses to GABA, and (3) by elevating spike threshold and/or depressing repetitive spike firing. Bathing neurons with picrotoxin induced 'convulsive-like' activity which was attenuated by flurazepam. The direct effects of flurazepam on the passive and active properties of membrane excitability were insensitive to picrotoxin. However, when the dose of flurazepam was increased to 10 nM or greater this drug lost its effectiveness. These results show that flurazepam is a potent drug with multiple sites of action all of which are likely to contribute to its pharmacological actions in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-64
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Multiple actions of picomolar concentrations of flurazepam on the excitability of cultured mouse spinal neurons.
pubmed:publicationType
Journal Article