| pubmed-article:7126425 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C0042153 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C0003968 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C1510471 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:7126425 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7126425 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7126425 | pubmed:dateCreated | 1982-12-16 | lld:pubmed |
| pubmed-article:7126425 | pubmed:abstractText | Plasma and buffy-coat vitamin C were estimated in 158 samples from 139 lung-cancer patients, at all stages of the disease. Most samples showed hypovitaminosis C in both estimations: 64% had plasma, and 25% buffy-coat values below the thresholds for incipient clinical scurvy (0.3 mg% and 10 micrograms/10(8) cells respectively). Levels were diet-dependent and could be increased by oral supplements. Levels were low both in tumour-bearing patients and in those clinically free of disease after resection. The latter had particularly low values during the first 6 months, indicating the utilization of vitamin C in surgical repair. The vitamin C content of 13 primary lung tumours was assayed: tumours had a higher vitamin C content (mean 111.6 +/- 55.1 micrograms/g tissue) than normal lung (58.5 +/- 20.4 micrograms/g). Mononuclear cells from normal individuals show a higher vitamin C content than polymorphs, but in lung-cancer patients the expected correlation of buffy-coat vitamin C with the proportion of lymphocytes in peripheral blood was obscured by an inverse correlation in patients with relative lymphocytosis (greater than or equal to 25% lymphocytes), confirmed by an inverse correlation of the proportion of lymphocytes in peripheral blood with mononuclear-cell vitamin C in 14 patients in whom this was measured. These correlations were unaffected by controlling for plasma values, and indicate the utilization of vitamin C in lymphocyte-related anti-tumour mechanisms. Vitamin C is necessary for phagocytosis and for the expression of cell-mediated immunity. In view of the increasing circumstantial evidence that immune mechanisms exert some measure of control on tumour extension and metastasis in man, the effect of supplementation with vitamin C in lung-cancer patients on survival should be tested in a clinical trial. | lld:pubmed |
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| pubmed-article:7126425 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7126425 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7126425 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7126425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7126425 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7126425 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7126425 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:7126425 | pubmed:author | pubmed-author:AnthonyH MHM | lld:pubmed |
| pubmed-article:7126425 | pubmed:author | pubmed-author:SchorahC JCJ | lld:pubmed |
| pubmed-article:7126425 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7126425 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:7126425 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7126425 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7126425 | pubmed:pagination | 354-67 | lld:pubmed |
| pubmed-article:7126425 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7126425 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7126425 | pubmed:articleTitle | Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance. | lld:pubmed |
| pubmed-article:7126425 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7126425 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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