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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1982-12-16
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pubmed:abstractText |
Plasma and buffy-coat vitamin C were estimated in 158 samples from 139 lung-cancer patients, at all stages of the disease. Most samples showed hypovitaminosis C in both estimations: 64% had plasma, and 25% buffy-coat values below the thresholds for incipient clinical scurvy (0.3 mg% and 10 micrograms/10(8) cells respectively). Levels were diet-dependent and could be increased by oral supplements. Levels were low both in tumour-bearing patients and in those clinically free of disease after resection. The latter had particularly low values during the first 6 months, indicating the utilization of vitamin C in surgical repair. The vitamin C content of 13 primary lung tumours was assayed: tumours had a higher vitamin C content (mean 111.6 +/- 55.1 micrograms/g tissue) than normal lung (58.5 +/- 20.4 micrograms/g). Mononuclear cells from normal individuals show a higher vitamin C content than polymorphs, but in lung-cancer patients the expected correlation of buffy-coat vitamin C with the proportion of lymphocytes in peripheral blood was obscured by an inverse correlation in patients with relative lymphocytosis (greater than or equal to 25% lymphocytes), confirmed by an inverse correlation of the proportion of lymphocytes in peripheral blood with mononuclear-cell vitamin C in 14 patients in whom this was measured. These correlations were unaffected by controlling for plasma values, and indicate the utilization of vitamin C in lymphocyte-related anti-tumour mechanisms. Vitamin C is necessary for phagocytosis and for the expression of cell-mediated immunity. In view of the increasing circumstantial evidence that immune mechanisms exert some measure of control on tumour extension and metastasis in man, the effect of supplementation with vitamin C in lung-cancer patients on survival should be tested in a clinical trial.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-128367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-13493748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-13885487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-159710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-187316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-200424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-227557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-352590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-371790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-4423667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-4557673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-4688801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-4717661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-4745531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-487570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-489966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-5015020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-54235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-5444988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-550375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-5801785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-5936292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-619966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-6265123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-6266445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-7350124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-7378281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-775029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-839842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-869983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7126425-872035
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
354-67
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7126425-Adult,
pubmed-meshheading:7126425-Aged,
pubmed-meshheading:7126425-Ascorbic Acid,
pubmed-meshheading:7126425-Ascorbic Acid Deficiency,
pubmed-meshheading:7126425-Carcinoma, Bronchogenic,
pubmed-meshheading:7126425-Diet,
pubmed-meshheading:7126425-Female,
pubmed-meshheading:7126425-Humans,
pubmed-meshheading:7126425-Immunity, Innate,
pubmed-meshheading:7126425-Leukocyte Count,
pubmed-meshheading:7126425-Leukocytes,
pubmed-meshheading:7126425-Lung Neoplasms,
pubmed-meshheading:7126425-Lymphocytes,
pubmed-meshheading:7126425-Male,
pubmed-meshheading:7126425-Middle Aged,
pubmed-meshheading:7126425-Seasons
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pubmed:year |
1982
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pubmed:articleTitle |
Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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