Linked Life Data

7117744

Source:http://linkedlifedata.com/resource/pubmed/id/7117744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-12-2
pubmed:abstractText
The carcinogenicities of 2-methoxy-4-aminoazobenzene and 3-methoxy-4-aminoazobenzene (2-MeO-AAB and 3-MeO-AAB) and their N-hydroxy derivatives (N-OH-2-MeO-AAB and N-OH-3-MeO-AAB) were tested in (C3H X C57BL/6) F1 mice. Topical sc injections, twice weekly for 8 weeks, of 4 or 8 mumol of N-OH-3-MeO-AAB dissolved in 0.1 ml of olive oil containing 10% dimethyl sulfoxide induced fibrosarcomas at the site of application. Similar treatment with 3-MeO-AAB or 2-MeO-AAB as well as N-OH-2-MeO-AAB failed to induce sarcomas. Oral administration of 0.09% 3-MeO-AAB in the diet for 13 months induced hepatic tumors in female mice but not in males. 2-MeO-AAB did not induce tumors in male or female mice. The relationship between carcinogenicity, mutagenicity, the ability to induce unscheduled DNA synthesis, and the metabolism of these azo dyes is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0016-450X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Carcinogenicities of 3-methoxy-4-aminoazobenzene, N-hydroxy-3-methoxy-4-aminoazobenzene and related azo dyes in the mouse.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't