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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1982-9-10
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pubmed:abstractText |
Immunological and electrophysiological features were investigated in a patient with rheumatoid arthritis who developed myasthenic symptoms after 10 months of treatment with D-penicillamine (D-pen). After an initial rise, acetylcholine receptor (AChR) antibodies gradually fell from 24.4 nmole alpha-bungarotoxin bound/liter to 1.8 nmole/liter following withdrawal of the drug, and this was associated with clinical and electrophysiological improvement. Immunoglobuline synthesis by peripheral blood lymphocytes cultured with pokeweed mitogen and D-pen was significantly increased at D-pen concentrations of 10-100 micrograms/ml in 2 patients with D-pen associated myasthenia gravis and 1 out of 3 normal individuals. Furthermore, lymphocytes from 1 myasthenic patient synthesized detectable AChR antibodies in vitro, and the amount of receptor antibody produced was increased in the presence of the drug. This effect was most marked at a concentration of 10 micrograms/ml which is thought to approximate the concentration in vivo. Our results confirm the in vivo findings of others that D-pen may have different effects on immunoglobulin production in different individuals and may also enhance the snythesis of at least 1 autoantibody, the AChR antibody.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholinergic
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0148-639X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
328-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7099199-Adult,
pubmed-meshheading:7099199-Arthritis, Rheumatoid,
pubmed-meshheading:7099199-Autoantibodies,
pubmed-meshheading:7099199-Electromyography,
pubmed-meshheading:7099199-Female,
pubmed-meshheading:7099199-Humans,
pubmed-meshheading:7099199-Immunoglobulin G,
pubmed-meshheading:7099199-Immunoglobulin M,
pubmed-meshheading:7099199-Male,
pubmed-meshheading:7099199-Middle Aged,
pubmed-meshheading:7099199-Myasthenia Gravis,
pubmed-meshheading:7099199-Penicillamine,
pubmed-meshheading:7099199-Receptors, Cholinergic
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pubmed:year |
1982
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pubmed:articleTitle |
D-Penicillamine-associated myasthenia gravis: immunological and electrophysiological studies.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|