Linked Life Data

7097567

Source:http://linkedlifedata.com/resource/pubmed/id/7097567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-9-10
pubmed:abstractText
The relative importance of extrinsic and intrinsic factors for the differential sensitivity of Purkinje neurons in long-sleep (LS) and short-sleep (SS) lines of mice was investigated using cerebellar grafts to the anterior chamber of the eye. Cerebellar anlagen from fetal LS and SS donors survive and mature in oculo when grafted within and across lines. Mature cerebellar transplants from all four groups contained Purkinje cells that show sustained spontaneous discharge; excitation and inhibition are readily evoked by electrical stimulation of the surface of the graft. Superfusion of ethanol into the anterior chamber depresses Purkinje cell discharge, but neurons from LS donors are approximately 1 order of magnitude more sensitive than SS neurons; this differential sensitivity is unaltered by the host recipient line used. These data strongly suggest that the differential sensitivity of Purkinje cells to ethanol in the LS and SS mouse lines is an intrinsic property of the cerebellum.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
222
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
480-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Differential ethanol sensitivity of intraocular cerebellar grafts in long-sleep and short-sleep mice.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't